US 12,077,484 B2
Process for the synthesis of melphalan
Pietro Allegrini, Milan (IT); Andrea Bonetti, Milan (IT); Marco Molinari, Milan (IT); and Andrea Gambini, Milan (IT)
Assigned to Indena S.P.A., Milan (IT)
Filed by Indena S.P.A., Milan (IT)
Filed on May 19, 2023, as Appl. No. 18/320,326.
Application 18/320,326 is a division of application No. 17/757,830, granted, now 11,787,761, previously published as PCT/EP2020/087443, filed on Dec. 21, 2020.
Claims priority of application No. 102019000025348 (IT), filed on Dec. 23, 2019.
Prior Publication US 2023/0286901 A1, Sep. 14, 2023
Int. Cl. C07C 227/20 (2006.01)
CPC C07C 227/20 (2013.01) 3 Claims
 
1. A compound of formula (IV):

OG Complex Work Unit Chemistry
wherein R1 is a carboxy-protecting group and one of R2 and R3 is hydrogen and the other one is an amino protecting group or R2 and R3 together with the nitrogen atom they are bound to form an amino-protecting group, X is —OS(O)nO−, wherein n is 1 or 2, and M+ or M2+ is a metallic cation.