US 12,077,450 B2
Tantalum oxide nanoparticle contrast agents
Shatadru Chakravarty, Rolla, MO (US); and Erik M. Shapiro, Okemos, MI (US)
Assigned to Board of Trustees of Michigan State University, East Lansing, MI (US)
Filed by Board of Trustees of Michigan State University, East Lansing, MI (US)
Filed on Jul. 6, 2021, as Appl. No. 17/367,919.
Claims priority of provisional application 63/066,029, filed on Aug. 14, 2020.
Prior Publication US 2022/0048788 A1, Feb. 17, 2022
Int. Cl. C01G 35/00 (2006.01); A61K 47/69 (2017.01); A61K 49/04 (2006.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); G01N 23/046 (2018.01)
CPC C01G 35/00 (2013.01) [A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); A61K 49/0428 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01P 2004/64 (2013.01); C01P 2004/84 (2013.01); G01N 23/046 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A nanoparticle composition comprising:
a plurality of nanoparticles, each nanoparticle of the plurality having:
a core comprising tantalum oxide, and
a covalent coating covalently bound to the core, the covalent coating comprising a surface modifier comprising 2-[methoxy (polyethyleneoxy)-9-12-propyl] trimethoxysilane (PEG-Silane) and hexadecyltriethoxy silane.