US 12,076,720 B2
Fluid control
Steven Alexander Keatch, Stirling (GB); Phill Lowe, Stirling (GB); Brian McGuigan, Stirling (GB); Andrew Peter Phelan, Cheltenham (GB); and Aman Khan, Bedford (GB)
Assigned to LumiraDx UK Ltd., London (GB)
Filed by LumiraDx UK Ltd., London (GB)
Filed on Apr. 12, 2021, as Appl. No. 17/228,402.
Application 17/228,402 is a continuation of application No. 16/313,633, granted, now 11,000,847, previously published as PCT/GB2017/051946, filed on Jun. 30, 2017.
Claims priority of application No. 1611442 (GB), filed on Jun. 30, 2016.
Prior Publication US 2021/0402388 A1, Dec. 30, 2021
Int. Cl. B01L 3/00 (2006.01); F04B 13/00 (2006.01); F04B 35/01 (2006.01); F04B 43/04 (2006.01); F04B 45/067 (2006.01); F04B 45/08 (2006.01); F04F 1/02 (2006.01); F04F 1/10 (2006.01); H10N 30/20 (2023.01)
CPC B01L 3/50273 (2013.01) [B01L 3/502723 (2013.01); F04B 13/00 (2013.01); F04B 35/01 (2013.01); F04B 43/046 (2013.01); F04B 45/067 (2013.01); F04B 45/08 (2013.01); F04F 1/02 (2013.01); F04F 1/10 (2013.01); H10N 30/2042 (2023.02); B01L 2200/0668 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/123 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0484 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0688 (2013.01); B01L 2400/0694 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A self-contained, dry, planar microfluidic cartridge for use in conducting one or more assay(s) on a liquid sample, the microfluidic cartridge comprising:
a sample input port for receiving the liquid sample, the sample input port connected to at least one microfluidic channel at a first end of said microfluidic channel, wherein each/said microfluidic channel(s) comprises one or more reagents deposited therein for use in conducting the assay and a detection zone for use in detecting any analyte which may be present in the sample or analyte reaction product thereof; and
each/said microfluidic channel(s) is further fluidly connected to compressible gas-filled chamber disposed at a second end of each/said microfluidic channel(s) downstream from each/said deposited reagents and detection zone, wherein each/said gas-filled chamber lacks any valve or port that communicates with the outside of the strip, and wherein the self-contained dry planar microfluidic cartridge does not contain liquid prior to the application of a sample and comprises three resilient planar layers, which are sandwiched together to define each/said microfluidic channel(s) and each/said gas-filled chamber(s) and wherein said gas-filled chamber(s) are configured to be compressed, thereby causing the gas-filled chamber to be deformed and gas to be expelled from the gas-filled chamber(s) and upon decompressing the gas-filled chamber(s), the gas-filled chamber(s) are configured to return to its non-deformed state, and whereby gas is configured to be drawn back into the gas-filled chamber(s), wherein said compression and decompression in turn is configured to cause reciprocal movement of the liquid sample within said/each microfluidic channel.