US 12,076,694 B2
Method of removing protein-bound substances by electrically conductive polymer
Yu-Sheng Hsiao, New Taipei (TW); Shih-Chieh Yen, New Taipei (TW); and Chia-Hung Su, New Taipei (TW)
Assigned to Ming Chi University of Technology, New Taipei (TW)
Filed by Yu-Sheng Hsiao, New Taipei (TW); Shih-Chieh Yen, New Taipei (TW); and Chia-Hung Su, New Taipei (TW)
Filed on Aug. 30, 2023, as Appl. No. 18/239,772.
Application 18/239,772 is a continuation of application No. 17/026,234, filed on Sep. 20, 2020, abandoned.
Claims priority of provisional application 62/903,954, filed on Sep. 23, 2019.
Prior Publication US 2023/0405532 A1, Dec. 21, 2023
Int. Cl. B01D 71/68 (2006.01); A61M 1/16 (2006.01); B01D 61/24 (2006.01); B01D 61/30 (2006.01); C08J 3/21 (2006.01); C08L 65/00 (2006.01); D01D 1/02 (2006.01); D01D 5/00 (2006.01); D01F 1/09 (2006.01)
CPC B01D 71/68 (2013.01) [A61M 1/1621 (2014.02); B01D 61/243 (2013.01); B01D 61/30 (2013.01); C08J 3/212 (2013.01); C08L 65/00 (2013.01); D01D 1/02 (2013.01); D01D 5/003 (2013.01); D01F 1/09 (2013.01); B01D 2311/2626 (2013.01); B01D 2311/2684 (2013.01); B01D 2313/345 (2013.01); C08L 2203/12 (2013.01); C08L 2203/20 (2013.01); C08L 2312/08 (2013.01); D10B 2509/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of removing protein-bound substances by an electrically conductive polymer, comprising:
(a) providing a (3-glycidyloxypropyl)trimethoxysilane: polystyrenesulfonate (PEDOT:PSS) solution including carbon nanotubes and a crosslinking agent;
(b) blending the PEDOT:PSS solution with an additive solution to acquire a quaternary blend solution;
(c) electrospinning the quaternary blend solution to form the electrically conductive polymer;
(d) using a first electrode and the electrically conductive polymer as a second electrode to coat on a dialysis membrane to acquire a bioelectronic interface device;
(e) introducing a biological fluid sample to the bioelectronic interface device; and
(f) providing an electrical stimulation to reduce binding rate between proteins and the protein-bound substances,
wherein the additive solution is ranged 5˜30 wt % based on a total weight of the quaternary blend solution,
wherein the additive solution comprises polyethylene oxide (PEO) solution, polyvinyl alcohol (PVA) solution, polyethyleneimine (PEI) solution, poly(acrylic acid) (PAA) solution, poly(styrenesulfonate) (PSS) solution, polyvinylpyrrolidone (PVP) solution, polyacrylamide (PAM) solution, poly(ethyl exazoline) solution, poly-lysine solution, poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) triblock copolymers solution, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymer solution, an alginate solution, hyaluronic acid (HA) solution, a gelatin solution, a collagen solution, polyglutamic acid (PGA) solution, a chitin solution, a chitosan solution, a cellulose solution or a combination thereof.