US 12,076,581 B2
Diffusing alpha-emitter radiation therapy for glioblastoma
Itzhak Kelson, Tel Aviv (IL); Yona Keisari, Ramat Gan (IL); Amnon Gat, Matan (IL); Robert Den, Merion Station, PA (US); Ofer Magen, Hod Hasharon (IL); Vered Domankevich, Hod Hasharon (IL); Lior Arazi, Tel Aviv (IL); Tomer Cooks, Gedera (IL); Guy Heger, Ramat Gan (IL); Mirta Dumancić, Beer Sheva (IL); Ishai Luz, Kibbutz Gevim (IL); and Maayan Hedva Vatarescu, Lehavim (IL)
Assigned to ALPHA TAU MEDICAL LTD., Jerusalem (IL)
Filed by ALPHA TAU MEDICAL LTD., Jerusalem (IL)
Filed on Jan. 9, 2023, as Appl. No. 18/094,419.
Application 18/094,419 is a continuation of application No. PCT/IB2022/055326, filed on Jun. 8, 2022.
Application PCT/IB2022/055326 is a continuation in part of application No. 17/343,783, filed on Jun. 10, 2021.
Prior Publication US 2023/0158329 A1, May 25, 2023
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1007 (2013.01) [A61N 5/1031 (2013.01); A61N 5/1071 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method for treating a glioblastoma tumor, comprising:
identifying a tumor as a glioblastoma tumor; and
implanting in the tumor identified as a glioblastoma tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the at least one DaRT source provides during the given duration a cumulated activity of released radon between 6.5 Mega becquerel (MBq) hour and 14.3 MBq hour, per centimeter length,
wherein implanting the at least one DaRT source comprises implanting a plurality of DaRT sources, each DaRT source separated from its neighboring DaRT sources by less than 3.9 millimeters.