US 12,076,566 B2
Neurostimulation titration utilizing T-wave alternans
Imad Libbus, St. Paul, MN (US); and Bruce H. KenKnight, Maple Grove, MN (US)
Assigned to LivaNova USA, Inc., Houston, TX (US)
Filed by LivaNova USA, Inc., Houston, TX (US)
Filed on Dec. 21, 2020, as Appl. No. 17/129,467.
Application 17/129,467 is a continuation of application No. 16/159,415, filed on Oct. 12, 2018, granted, now 10,870,005.
Application 16/159,415 is a continuation of application No. 14/938,641, filed on Nov. 11, 2015, granted, now 10,099,055.
Claims priority of provisional application 62/078,600, filed on Nov. 12, 2014.
Prior Publication US 2021/0178163 A1, Jun. 17, 2021
Int. Cl. A61N 1/36 (2006.01); A61B 5/349 (2021.01); A61N 1/05 (2006.01); A61N 1/37 (2006.01); A61N 1/372 (2006.01); G16H 20/30 (2018.01); G16H 20/40 (2018.01); G16H 40/20 (2018.01); G16H 40/63 (2018.01); G16Z 99/00 (2019.01)
CPC A61N 1/36139 (2013.01) [A61B 5/349 (2021.01); A61N 1/0551 (2013.01); A61N 1/36114 (2013.01); A61N 1/36132 (2013.01); A61N 1/3615 (2013.01); A61N 1/36167 (2013.01); A61N 1/3702 (2013.01); A61N 1/37223 (2013.01); A61N 1/37235 (2013.01); G16H 20/30 (2018.01); G16H 20/40 (2018.01); G16H 40/20 (2018.01); G16H 40/63 (2018.01); G16Z 99/00 (2019.02)] 14 Claims
OG exemplary drawing
 
1. A method of operating an implantable medical device (IMD) comprising a neurostimulator coupled to an electrode assembly, said neurostimulator adapted to deliver a stimulation signal to a patient, said method comprising:
activating the IMD to deliver the stimulation signal to the patient;
monitoring a T-wave alternans (TWA) magnitude value for the patient while delivering the stimulation signal to the patient;
transmitting the TWA magnitude value for the patient to an external device to be communicated to a health care provider; and
adjusting, based on the TWA magnitude value being above a threshold value, an intensity of the stimulation signal until a target TWA change is achieved, wherein the stimulation signal is adjusted in accordance with an instruction provided via the external device by the health care provider.