US 12,076,542 B2
Applicator for cryoanesthesia and analgesia
Cagri Giray Besirli, Ann Arbor, MI (US); Stephen Smith, Mountain View, CA (US); Kevin P. Pipe, Ann Arbor, MI (US); and Gun-Ho Kim, Ulsan (KR)
Assigned to The Regents of The University of Michigan, Ann Arbor, MI (US)
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Filed on Jun. 22, 2022, as Appl. No. 17/846,437.
Application 17/846,437 is a continuation of application No. 16/273,252, filed on Feb. 12, 2019, granted, now 11,389,600.
Application 16/273,252 is a continuation of application No. 16/136,416, filed on Sep. 20, 2018, granted, now 10,238,814, issued on Mar. 26, 2019.
Application 16/136,416 is a continuation of application No. 15/079,132, filed on Mar. 24, 2016, granted, now 10,322,248, issued on Jun. 18, 2019.
Claims priority of provisional application 62/237,793, filed on Oct. 6, 2015.
Claims priority of provisional application 62/138,444, filed on Mar. 26, 2015.
Prior Publication US 2022/0379043 A1, Dec. 1, 2022
Int. Cl. A61F 7/00 (2006.01); A61M 5/315 (2006.01); A61M 5/32 (2006.01); A61M 5/42 (2006.01); A61F 9/00 (2006.01); A61M 5/20 (2006.01)
CPC A61M 5/422 (2013.01) [A61F 7/00 (2013.01); A61F 7/007 (2013.01); A61M 5/315 (2013.01); A61M 5/322 (2013.01); A61F 2007/0004 (2013.01); A61F 2007/0052 (2013.01); A61F 2007/0075 (2013.01); A61F 2007/0078 (2013.01); A61F 2007/0086 (2013.01); A61F 2007/0087 (2013.01); A61F 2007/0095 (2013.01); A61F 9/0008 (2013.01); A61M 5/20 (2013.01); A61M 2005/206 (2013.01); A61M 2202/048 (2013.01); A61M 2210/0612 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A device for cooling a target area of a cutaneous membrane, a mucous membrane, or tissue of a mucocutaneous zone, the device comprising:
an elongated body having a gripping portion to facilitate handheld manipulation by a user, the elongated body having a proximal end and a distal end, the elongated body comprising:
a cooling system configured to cool the target area to a temperature ranging between 0° C. and −80° C. to induce anesthesia or analgesia in the target area, wherein the cooling system comprises:
a compression cooling system, and
a temperature sensor and feedback loops to maintain tightly regulated temperature; and
a controller for controlling the cooling system; and
an intravitreal injection system having a drug container and injection needle.