US 12,076,470 B2
Bioartificial ultrafiltration device and methods related thereto
Shuvo Roy, San Ramon, CA (US); Rishi Kant, Foster City, CA (US); Andrew Posselt, Mill Valley, CA (US); Shang Song, Redwood City, CA (US); Willieford Moses, Oakland, CA (US); and Charles Blaha, San Francisco, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on May 3, 2023, as Appl. No. 18/143,005.
Application 18/143,005 is a continuation of application No. 17/343,361, filed on Jun. 9, 2021, granted, now 11,666,691.
Application 17/343,361 is a continuation of application No. 16/082,501, granted, now 11,033,668, issued on Jun. 15, 2021, previously published as PCT/US2017/021196, filed on Mar. 7, 2017.
Claims priority of provisional application 62/328,298, filed on Apr. 27, 2016.
Claims priority of provisional application 62/304,758, filed on Mar. 7, 2016.
Prior Publication US 2024/0075193 A1, Mar. 7, 2024
Int. Cl. A61M 1/16 (2006.01); A61B 5/15 (2006.01); A61M 1/36 (2006.01); B01D 61/14 (2006.01); B01D 63/08 (2006.01); B01D 67/00 (2006.01); B01D 69/02 (2006.01); B01D 69/08 (2006.01); B01D 71/02 (2006.01); B01D 71/70 (2006.01); B01D 69/14 (2006.01)
CPC A61M 1/1678 (2013.01) [A61B 5/150992 (2013.01); A61M 1/3689 (2014.02); B01D 61/145 (2013.01); B01D 67/0037 (2013.01); B01D 67/0072 (2013.01); B01D 69/02 (2013.01); B01D 69/08 (2013.01); B01D 71/027 (2013.01); B01D 71/70 (2013.01); A61M 2202/09 (2013.01); A61M 2205/04 (2013.01); B01D 69/145 (2013.01); B01D 2325/021 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
(A) an ultrafiltration device comprising:
a first planar scaffold and a second planar scaffold each comprising a matrix comprising a plurality of channels extending from a first surface to a second surface of each of the planar scaffolds;
a first semipermeable ultrafiltration membrane disposed on the first surface of the first and second planar scaffolds;
a first compartment adjacent to and sandwiched between the first surface of the first and second planar scaffolds and comprising an inlet and an outlet, wherein the first semipermeable ultrafiltration membrane allows transport of ultrafiltrate from the first compartment to the scaffolds;
a second compartment adjacent to the second surface of the first planar scaffold and comprising an inlet and an outlet; and
a third compartment adjacent to the second surface of the second planar scaffold and comprising an inlet and an outlet;
wherein the first semipermeable ultrafiltration membrane comprises a plurality of pores, and
wherein the ultrafiltrate traverses from the plurality of channels in the scaffolds into the second compartment and the third compartment; and
(B) a housing that contains the ultrafiltration device and comprises:
a blood inlet port operably connected to a first end of the first compartment;
a blood outlet port operably connected to second end of the first compartment;
an ultrafiltrate outlet operably connected to the second compartment and third compartment.