US 12,076,462 B2
Hydratable compositions comprising macroparticles and methods of making them
Gretchen Selders, Memphis, TN (US); and Ian Dunkley, Memphis, TN (US)
Assigned to Warsaw Orthopedic, Inc., Warsaw, IN (US)
Filed by WARSAW ORTHOPEDIC, INC., Warsaw, IN (US)
Filed on Sep. 11, 2020, as Appl. No. 17/018,708.
Claims priority of provisional application 62/898,924, filed on Sep. 11, 2019.
Prior Publication US 2021/0069382 A1, Mar. 11, 2021
Int. Cl. A61L 27/46 (2006.01); A61L 27/10 (2006.01); A61L 27/12 (2006.01); A61L 27/24 (2006.01); A61L 27/36 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/46 (2013.01) [A61L 27/10 (2013.01); A61L 27/12 (2013.01); A61L 27/24 (2013.01); A61L 27/3608 (2013.01); A61L 27/362 (2013.01); A61L 27/365 (2013.01); A61L 27/56 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01)] 16 Claims
 
1. A method of making a uniformly hydrated composition, the method comprising providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition, wherein the ceramic material comprises hydroxyapatite and beta-tricalcium phosphate having a calcium to phosphate ratio of between 1.0 to about 2.0, and the ceramic material is in the form of macroparticles having an average diameter from about 4 mm to about 6 mm and a density of 0.1 to 0.6 g/cc.