US 12,076,460 B2
Demineralized bone matrix fibers, methods of making and using them
Gregory Scott McGraw, Memphis, TN (US); and David R. Kaes, Toms River, NJ (US)
Assigned to Warsaw Orthopedic, Inc., Warsaw, IN (US)
Filed by WARSAW ORTHOPEDIC, INC., Warsaw, IN (US)
Filed on Sep. 11, 2020, as Appl. No. 17/018,491.
Claims priority of provisional application 62/898,964, filed on Sep. 11, 2019.
Prior Publication US 2021/0069380 A1, Mar. 11, 2021
Int. Cl. A61L 27/36 (2006.01); B29B 9/14 (2006.01); B29K 105/08 (2006.01); B29K 105/12 (2006.01); B29K 311/06 (2006.01)
CPC A61L 27/3608 (2013.01) [A61L 27/3616 (2013.01); A61L 27/365 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); B29B 9/14 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); B29K 2105/08 (2013.01); B29K 2105/12 (2013.01); B29K 2311/06 (2013.01)] 13 Claims
 
1. A method of preparing a demineralized bone matrix pellet, the method comprising providing a plurality of first bone fibers having a diameter from about 0.6 mm to about 8.0 mm; mixing the plurality of first bone fibers with a plurality of second bone fibers having a diameter from about 0.5 mm to about 0.05 mm to form a mixture of first bone fibers and second bone fibers; demineralizing the mixture of first bone fibers and second bone fibers to form a demineralized bone matrix slurry; adding the demineralized bone matrix slurry to a mold; and drying the demineralized bone matrix slurry to form a demineralized bone matrix pellet in the mold, wherein the first bone fibers have their diameter larger relative to the diameter of the second bone fibers, wherein the ratio of first bone fibers to second bone fibers is about 80:20 respectively or about 90:10 respectively in the mixture.