US 12,076,444 B2
Methods and systems for depositing active ingredients on substrates
Arun V. Giridhar, West Lafayette, IN (US); Michael Harris, West Lafayette, IN (US); Gintaras V. Reklaitis, West Lafaytte, IN (US); Lynne S. Taylor, West Lafaytte, IN (US); Zoltan K. Nagy, West Lafayette, IN (US); Elcin Icten, West Lafayette, IN (US); Frederick Fiesser, Philadelphia, PA (US); and Laura Hirshfield, Ann Arbor, MI (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on Jan. 10, 2023, as Appl. No. 18/152,394.
Application 18/152,394 is a continuation of application No. 15/751,771, granted, now 11,547,675, issued on Jan. 10, 2023, previously published as PCT/US2016/046217, filed on Aug. 9, 2016.
Claims priority of provisional application 62/203,013, filed on Aug. 10, 2015.
Prior Publication US 2023/0233479 A1, Jul. 27, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/415 (2006.01); A61K 31/635 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/34 (2017.01); A61K 47/38 (2006.01); B01J 4/00 (2006.01); B01J 4/02 (2006.01)
CPC A61K 9/7007 (2013.01) [A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/415 (2013.01); A61K 31/635 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01); B01J 4/002 (2013.01); B01J 4/008 (2013.01); B01J 4/02 (2013.01); B01J 2204/005 (2013.01); B01J 2204/007 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An active ingredient delivery system comprising:
a fluid reservoir;
a fluid-delivery apparatus in contact with the reservoir, the fluid-delivery apparatus comprising:
a pump connected to a controller that allows for adjustment of at least in volume strokes, pump velocity, or both volume strokes and pump velocity via a computer executable program or manual operation, and
a fluid-dispensing device comprising a first end in fluid communication with the fluid reservoir via a fluid transfer tube positioned inside a heated air tube, and a second end for dispensing fluid as droplets,
wherein the pump is positioned to transfer a fluid from the reservoir, through the pump, and to and through the fluid-dispensing device;
a real-time drop-imaging and measurement device; and
a substrate holder comprising a stage to receive droplets from the second end of the fluid-dispensing device and a substrate positioned on the stage.