US 12,076,429 B2
Estolide composition for topical applications
Delphine Crozet, Villeurbanne (FR); Alice Limoges, Ternay (FR); and Benjamin Swoboda, Orgeval (FR)
Assigned to TOTALENERGIES ONETECH, Courbevoie (FR)
Appl. No. 17/909,038
Filed by TOTALENERGIES ONETECH, Courbevoie (FR)
PCT Filed Mar. 17, 2021, PCT No. PCT/FR2021/050440
§ 371(c)(1), (2) Date Sep. 2, 2022,
PCT Pub. No. WO2021/186131, PCT Pub. Date Sep. 23, 2021.
Claims priority of application No. 2002719 (FR), filed on Mar. 19, 2020.
Prior Publication US 2023/0107326 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/37 (2006.01); A61K 8/34 (2006.01); A61K 8/36 (2006.01); A61Q 1/00 (2006.01); C07C 69/675 (2006.01)
CPC A61K 8/37 (2013.01) [A61K 8/34 (2013.01); A61K 8/361 (2013.01); A61Q 1/00 (2013.01); C07C 69/675 (2013.01); A61K 2800/10 (2013.01)] 18 Claims
 
1. An estolide ester composition obtained by the process comprising:
a) an addition reaction of a saturated fatty acid composition (C1) to an unsaturated fatty acid composition (C2) in the presence of a catalyst in order to obtain an acid estolide composition (C3), and
b) optionally, a treatment step for removing unsaturated fatty acids and/or saturated fatty acids from the acid estolide composition (C3) and/or a separation step for separating the acid monoestolides from the acid polyestolides present in the acid estolide composition (C3) in order to obtain a treated acid estolide composition (C3bis), and
c) an esterification reaction of the acid estolides of the acid estolide composition (C3), or, if any, of the treated acid estolide composition (C3bis), using an alcohol composition (C4) comprising one or more linear or branched alcohols with 2 to 6 carbon atoms, in order to obtain an estolide ester composition (C5),
said saturated fatty acid composition (C1) comprising saturated fatty acids with 10 to 20 carbon atoms,
said unsaturated fatty acid composition (C2) comprising at least 85% by weight of mono-unsaturated fatty acids with 8 to 22 carbon atoms, with respect to the total weight of the unsaturated fatty acid composition (C2).