US 12,076,401 B2
Benzamide and active compound compositions and methods of use
Tong Wang, Scottsdale, AZ (US); Stephen Gately, Scottsdale, AZ (US); and Paul Gonzales, Scottsdale, AZ (US)
Assigned to Translational Drug Development, LLC, Scottsdale, AZ (US)
Filed by TRANSLATIONAL DRUG DEVELOPMENT, LLC, Scottsdale, AZ (US)
Filed on Dec. 2, 2020, as Appl. No. 17/110,008.
Application 17/110,008 is a continuation in part of application No. 16/644,457, granted, now 11,236,052, previously published as PCT/US2018/049801, filed on Sep. 6, 2018.
Application 17/110,008 is a continuation in part of application No. 16/074,706, filed on Aug. 1, 2018, abandoned.
Application 17/110,008 is a continuation in part of application No. 15/575,340, previously published as PCT/US2016/033841, filed on May 23, 2016.
Claims priority of provisional application 62/554,728, filed on Sep. 6, 2017.
Claims priority of provisional application 62/302,781, filed on Mar. 2, 2016.
Claims priority of provisional application 62/167,794, filed on May 28, 2015.
Claims priority of provisional application 62/167,790, filed on May 28, 2015.
Claims priority of provisional application 62/165,891, filed on May 22, 2015.
Prior Publication US 2021/0093717 A1, Apr. 1, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/04 (2006.01); A61K 31/4184 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07D 235/30 (2006.01); C07D 403/04 (2006.01); C07K 16/28 (2006.01); A61K 31/7068 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/3955 (2013.01) [A61K 31/4184 (2013.01); A61K 45/06 (2013.01); A61K 47/18 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07D 235/30 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07K 16/2818 (2013.01); A61K 31/7068 (2013.01); A61K 2039/507 (2013.01); A61K 2300/00 (2013.01); C07K 2317/76 (2013.01)] 20 Claims
 
1. A compound selected from the group consisting of:
4-((1-(cyclohexylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #24

OG Complex Work Unit Chemistry
4-((1-((1-fluorocyclohexyl)methyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #27

OG Complex Work Unit Chemistry
4-((1-(cyclopentylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #28

OG Complex Work Unit Chemistry
4-((1-(2-cyclopentylethyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #29

OG Complex Work Unit Chemistry
4-((1-((4,4-difluorocyclohexyl)methyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #30

OG Complex Work Unit Chemistry
4-((1-((4,4-difluorocyclohexyl)methyl)-5-fluoro-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #31

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N-hydroxy-4-((1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)amino)benzamide ID #32

OG Complex Work Unit Chemistry
 and
4-((5-fluoro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)amino)-N-hydroxybenzamide ID #33

OG Complex Work Unit Chemistry