US 12,076,357 B2
Preparations containing berry extracts for use in the prophylaxis and/or treatment of viral infections caused by Paramyxoviridae
Jean-Luc Herbeaux, Cascais (PT); Norbert Windhab, Hofheim (DE); Anne Benedikt, Frankfurt (DE); Andrea Engel, Birmingham, AL (US); Maria Steinke, Höchberg (DE); and Jochen Bodem, Geroldshausen (DE)
Assigned to Evonik Operations GmbH, Essen (DE)
Appl. No. 17/598,487
Filed by Evonik Operations GmbH, Essen (DE)
PCT Filed Mar. 27, 2020, PCT No. PCT/EP2020/058642
§ 371(c)(1), (2) Date Sep. 27, 2021,
PCT Pub. No. WO2020/201042, PCT Pub. Date Oct. 8, 2020.
Claims priority of application No. 19166036 (EP), filed on Mar. 29, 2019; and application No. 19166060 (EP), filed on Mar. 29, 2019.
Prior Publication US 2022/0184163 A1, Jun. 16, 2022
Int. Cl. A61K 36/45 (2006.01); A61K 9/00 (2006.01); A61K 31/7048 (2006.01); A61K 36/185 (2006.01); A61K 45/06 (2006.01); A61P 31/14 (2006.01)
CPC A61K 36/45 (2013.01) [A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0078 (2013.01); A61K 9/0095 (2013.01); A61K 31/7048 (2013.01); A61K 36/185 (2013.01); A61K 45/06 (2013.01); A61P 31/14 (2018.01); A61K 2236/333 (2013.01); A61K 2236/51 (2013.01); A61K 2236/53 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for treating a viral infection in a subject comprising:
administering to a subject a synergistic amount of a composition comprising a combined extract of black currants and bilberries,
wherein the virus is selected from the Paramyxoviridae family,
wherein the combined extract of black currants and bilberries has an anthocyanin content of 29.7% by weight of the extract,
wherein the combined extract of black currants and bilberries comprises a relative anthocyanin content of:
33.0% of 3-O-b-rutinoside, 3-O-b-glucosides, 3-O-b-galactosides, and 3-O-b-arabinosides of cyanidin,
58.0% of 3-O-b-rutinoside, 3-O-b-glucosides, 3-O-b-galactosides, and 3-O-b-arabinosides of delphinidin,
2.5% of 3-O-b-glucosides, 3-O-b-galactosides, and 3-O-b-arabinosides of petunidin,
2.5% of 3-O-b-glucosides, 3-O-b-galactosides, and 3-O-b-arabinosides of peonidin, and
3.0% of 3-O-b-glucosides, 3-O-b-galactosides, and 3-O-b-arabinosides of malvidin,
wherein the extracts of black currant and bilberries are in a weight ratio of 1:1.