US 12,076,341 B2
Use of apoptotic compensatory proliferation signaling vesicles in tissue repair and wound healing
Sasha Shafikhani, Elmwood Park, IL (US)
Assigned to Rush University Medical Center, Chicago, IL (US)
Appl. No. 17/252,782
Filed by Rush University Medical Center, Chicago, IL (US)
PCT Filed Jun. 18, 2019, PCT No. PCT/US2019/037614
§ 371(c)(1), (2) Date Dec. 16, 2020,
PCT Pub. No. WO2019/246019, PCT Pub. Date Dec. 26, 2019.
Claims priority of provisional application 62/686,448, filed on Jun. 18, 2018.
Prior Publication US 2021/0260109 A1, Aug. 26, 2021
Int. Cl. A61K 35/13 (2015.01); A61K 9/127 (2006.01); A61P 17/02 (2006.01)
CPC A61K 35/13 (2013.01) [A61K 9/127 (2013.01); A61P 17/02 (2018.01)] 17 Claims
 
1. A method of treating a wound in an injured or diseased tissue, the method comprising:
administering a therapeutically effective amount dose of apoptotic compensatory proliferation signaling vesicles (ACPSVs) to the injured or diseased tissue
wherein the dose is about 15 ng/mm2 to about 25 ng/mm2; and
wherein the wound size is reduced by about 50%.