US 12,076,320 B2
Diarylpyrazole compound, composition comprising same, and use thereof
Yihan Wang, Guangdong (CN); and Zhiqiang Liu, Guangdong (CN)
Assigned to Shenzhen TargetRx, Inc., Guangdong (CN)
Appl. No. 17/259,472
Filed by Shenzhen TargetRx, Inc., Guangdong (CN)
PCT Filed Jul. 9, 2019, PCT No. PCT/CN2019/095169
§ 371(c)(1), (2) Date Jan. 11, 2021,
PCT Pub. No. WO2020/011141, PCT Pub. Date Jan. 16, 2020.
Claims priority of application No. 201810764742.X (CN), filed on Jul. 12, 2018.
Prior Publication US 2021/0283132 A1, Sep. 16, 2021
Int. Cl. A61K 31/506 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 403/04 (2006.01)
CPC A61K 31/506 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 403/04 (2013.01); C07B 2200/05 (2013.01); C07B 2200/13 (2013.01)] 9 Claims
 
1. A compound of:

OG Complex Work Unit Chemistry
or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof,
wherein each occurrence of the term “D” indicates a 2H content of more than 50%.