| CPC A61K 31/485 (2013.01) [A61K 47/542 (2017.08); A61K 45/06 (2013.01)] | 15 Claims |
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1. A compound of Formula 1:
 where L1 and L2 are independently absent, or
 Y1 and Y2 are independently either absent, or [A-X—Z]n where A, X, Z are independently selected for Y1 and Y2 and where A and Z are independent of each other, either absent or selected from the group of —O—, —S—, or —(CR1R2)k—,
where X is —(CR1R2)k—,
J is [M-W]p
where M is —(CR3R4)q—; and W is absent, or —O— or —S—
R1, and R2, are each independently selected for Y1 and Y2, and are, independent of each other, selected from H, alkyl, aryl, alkyl aryl, alkoxy, haloalkyl, or haloaryl
R3 and R4 are each independently selected from H, alkyl, aryl, alkyl aryl, alkoxy, haloalkyl, or haloaryl
for each Y1 and Y2, n is independently an integer of 1-4
for each repeating unit of [A-X—Z]n, when (CR1R2) is present, k is independently an integer of 1-4
p and q are independently selected from 1-4
Gm is absent, or selected independently of each other and, when present, each repeating subunit is independently selected from H, oxoacid, polyethylene glycol having from 2 to 5 ethylene oxide units, or a vitamin compound;
Gm2 is selected from oxoacid, polyethylene glycol having from 2 to 5 ethylene oxide units, or a vitamin compound;
where m is selected independently for G1 and G2, and is an integer of 1-4, except that m is 1 when G1 is a hydrogen atom;
or a pharmaceutically acceptable salt thereof.
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