	US 12,076,301 B2
	Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
Daniel C. Lu, Los Angeles, CA (US); V. Reggie Edgerton, Los Angeles, CA (US); Roland R. Roy, Playa Vista, CA (US); and Yury P. Gerasimenko, Los Angeles, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Aug. 19, 2021, as Appl. No. 17/407,043.
Application 17/407,043 is a continuation of application No. 16/200,467, filed on Nov. 26, 2018, granted, now 11,123,312.
Application 16/200,467 is a continuation of application No. 15/025,201, granted, now 10,137,299, issued on Nov. 27, 2018, previously published as PCT/US2014/057886, filed on Sep. 26, 2014.
Claims priority of provisional application 61/883,694, filed on Sep. 27, 2013.
Prior Publication US 2021/0378991 A1, Dec. 9, 2021
Int. Cl. A61K 31/137 (2006.01); A61K 31/4168 (2006.01); A61K 31/4178 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/527 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01)

CPC A61K 31/137 (2013.01) [A61K 31/4168 (2013.01); A61K 31/4178 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/527 (2013.01); A61N 1/0551 (2013.01); A61N 1/36003 (2013.01); A61N 1/36034 (2017.08); A61N 1/36067 (2013.01); A61N 1/36171 (2013.01)]

20 Claims

1. An electrical stimulation system, comprising:

a pulse generator configured to neuromodulate the cervical spinal cord of a patient by providing an electrical signal to at least one surface stimulation electrode attached to a dorsal aspect of the neck of the patient; and

wherein at least one of an amplitude and a frequency of the electrical signal are selected to improve, when the electrical signal is provided to the at least one surface stimulation electrode, at least one of voluntary motor control or grip strength of a hand of the patient.