US 12,076,278 B2
Method for modifying the refractive index of ocular tissues and applications thereof
Wayne H. Knox, Rochester, NY (US); and Krystel R. Huxlin, Rush, NY (US)
Assigned to University of Rochester, Rochester, NY (US)
Filed by University of Rochester, Rochester, NY (US)
Filed on May 17, 2023, as Appl. No. 18/198,509.
Application 18/198,509 is a continuation of application No. 17/072,286, filed on Oct. 16, 2020, granted, now 11,690,759.
Application 17/072,286 is a continuation of application No. 13/326,403, filed on Dec. 15, 2011, granted, now 10,813,791, issued on Oct. 27, 2020.
Claims priority of provisional application 61/492,559, filed on Jun. 2, 2011.
Claims priority of provisional application 61/492,586, filed on Jun. 2, 2011.
Prior Publication US 2023/0346602 A1, Nov. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 9/008 (2006.01)
CPC A61F 9/00827 (2013.01) [A61F 9/00834 (2013.01); A61F 2009/00842 (2013.01); A61F 2009/00846 (2013.01); A61F 2009/0087 (2013.01); A61F 2009/00872 (2013.01); A61F 2009/0088 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for modifying a refractive property of ocular tissue in an eye, comprising:
creating at least one optically-modified gradient index (GRIN) layer in at least one of a corneal stroma of the eye and a crystalline lens of the eye, wherein the GRIN layer has a gradient index of refraction in at least one of at least two directions that are generally transverse to a direction of light propagation through the ocular tissue created by scanning a stream of laser pulses having a focal volume from a laser having a known average power along a scan line; and
varying one or more laser parameters including laser average power during the scan;
further comprising varying the laser average power during the scan as a function of the gradient index of refraction along the scan line.