US 12,076,270 B2
Whole-body hyperthermia system
Johan Van Den Bossche, Linden (BE); Liesbet Conings, Linden (BE); and Johannes Bogers, Boechout (BE)
Assigned to ELMEDIX NV, Leuven (BE)
Appl. No. 16/345,920
Filed by ELMEDIX NV, Leuven (BE)
PCT Filed Oct. 31, 2017, PCT No. PCT/EP2017/077932
§ 371(c)(1), (2) Date Apr. 29, 2019,
PCT Pub. No. WO2018/078188, PCT Pub. Date May 3, 2018.
Claims priority of application No. 1618318 (GB), filed on Oct. 31, 2016; and application No. 17160450 (EP), filed on Mar. 10, 2017.
Prior Publication US 2020/0046548 A1, Feb. 13, 2020
Int. Cl. A61F 7/00 (2006.01); A61F 7/12 (2006.01); A61M 5/44 (2006.01); A61M 16/10 (2006.01); A61N 5/06 (2006.01)
CPC A61F 7/0053 (2013.01) [A61F 7/0085 (2013.01); A61F 7/12 (2013.01); A61M 5/445 (2013.01); A61M 16/1005 (2014.02); A61M 16/104 (2013.01); A61M 16/1075 (2013.01); A61N 5/0625 (2013.01); A61F 2007/0002 (2013.01); A61F 2007/0055 (2013.01); A61F 2007/0057 (2013.01); A61F 2007/006 (2013.01); A61F 2007/0086 (2013.01); A61F 2007/0096 (2013.01); A61F 2007/126 (2013.01); A61M 2205/3372 (2013.01); A61M 2205/3606 (2013.01); A61M 2205/362 (2013.01); A61M 2210/0693 (2013.01); A61M 2210/1064 (2013.01); A61M 2210/1071 (2013.01); A61M 2210/1082 (2013.01); A61M 2230/50 (2013.01); A61N 2005/0659 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature Tb and for stabilizing said body temperature at said target temperature Tb, said system comprising:
a cabinet, in which the individual is located, said cabinet being provided with isolation and heating for heating the air of the cabinet, for maintaining an individual at an elevated temperature,
at least one thermal means, configured to raise said body temperature at a rate of at least 1° C./hour, and subsequently set to obtain and maintain the target temperature Tb of said individual,
wherein said at least one thermal means comprises a first thermal means for raising said body temperature at a rate of at least 1° C./hour,
wherein raising said body temperature by said first thermal means is not performed by external heating of the blood system and
wherein said first thermal means do not comprise an internally heated fluid circuit,
one or more devices to prevent or counter heat loss from the individual, said one or more devices being devices for heating liquids being introduced in the body, said liquids comprising one or more of nutrients, liquids for hydration, liquids with medicaments, and liquids with anaesthetics,
one or more sensors monitoring the temperature or heat flux of the individual, connected to controllers steering said devices to prevent or counter heat loss and steering the at least one thermal means,
wherein said first thermal means has at least a first portion and at least a second portion, wherein the at least first portion of the first thermal means is arranged to raise the body temperature of at least a first series of body parts of the individual to the target temperature Tb, and
wherein the at least second portion of the first thermal means is arranged to prevent at least a second series of body parts to exceed a target temperature Ts,
wherein the temperature Ts is lower than the temperature Tb,
wherein said second portion further includes means for cooling individual organs,
wherein said means for cooling individual organs are applied to the brain and at least one of the liver, the kidneys and the colon, and in that, said system further comprises means for bringing the individual under anaesthesia.