US 12,076,167 B2
Predictive weighting of hypotension profiling parameters
Feras Al Hatib, Irvine, CA (US); Zhongping Jian, Irvine, CA (US); and Sai Prasad Buddi, Costa Mesa, CA (US)
Assigned to EDWARDS LIFESCIENCES CORPORATION, Irvine, CA (US)
Filed by Edwards Lifesciences Corporation, Irvine, CA (US)
Filed on Jul. 13, 2020, as Appl. No. 16/927,233.
Application 16/927,233 is a continuation of application No. 15/634,918, filed on Jun. 27, 2017, granted, now 10,751,004.
Claims priority of provisional application 62/360,088, filed on Jul. 8, 2016.
Prior Publication US 2020/0337649 A1, Oct. 29, 2020
Int. Cl. A61B 5/021 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); G16H 50/30 (2018.01)
CPC A61B 5/7275 (2013.01) [A61B 5/02028 (2013.01); A61B 5/021 (2013.01); A61B 5/7239 (2013.01); A61B 5/746 (2013.01); G16H 50/30 (2018.01); A61B 5/02042 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A system for monitoring of arterial pressure of a patient and providing a warning to medical personnel of a predicted future hypotensive event, the system comprising:
a minimally invasive or non-invasive hemodynamic sensor that produces an analog hemodynamic sensor signal representative of an arterial pressure waveform of the patient;
an analog-to-digital converter that converts the analog hemodynamic sensor signal to digital hemodynamic data;
a system memory that stores hypotension prediction software code including a predictive weighting module;
a user interface that includes a sensory alarm that provides a sensory signal to warn medical personnel of the predicted future hypotensive event prior to the patient entering a hypotensive state; and
a hardware processor that is configured to execute the hypotension prediction software code to:
perform waveform analysis of the digital hemodynamic data to obtain vital sign parameters from the digital hemodynamic data representing the arterial pressure waveform;
derive differential parameters based on one or more of the vital sign parameters;
generate combinatorial parameters using one or more of the vital sign parameters and/or one or more of the differential parameters;
determine, using the predictive weighting module, a risk score representing a probability of a future hypotension event for the patient based on a weighted combination of a plurality of hypotension profiling parameters including the one or more of the vital sign parameters, the differential parameters and the combinatorial parameters; and
invoke the sensory alarm to produce the sensory signal in response to the risk score satisfying a predetermined risk criterion;
wherein the plurality of hypotension profiling parameters includes at least one of:
cardiac contractility;
kurtosis of the arterial pressure waveform within a beat; and
variability in the kurtosis of the arterial pressure waveform within a beat.