US 12,076,159 B2
Combining multiple QEEG features to estimate drug-independent sedation level using machine learning
Sunil Belur Nagaraj, Groningen (NL); Sowmya Muchukunte Ramaswamy, Groningen (NL); and Michel Maria R. Struys, Belsele (BE)
Assigned to Masimo Corporation, Irvine, CA (US)
Filed by Masimo Corporation, Irvine, CA (US)
Filed on Feb. 6, 2020, as Appl. No. 16/784,067.
Claims priority of provisional application 62/847,824, filed on May 14, 2019.
Claims priority of provisional application 62/802,575, filed on Feb. 7, 2019.
Prior Publication US 2020/0253544 A1, Aug. 13, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/316 (2021.01); A61B 5/369 (2021.01); G06N 7/01 (2023.01); G06N 20/10 (2019.01); G06N 20/20 (2019.01); G16H 20/17 (2018.01)
CPC A61B 5/4821 (2013.01) [A61B 5/316 (2021.01); A61B 5/369 (2021.01); A61B 5/7246 (2013.01); A61B 5/7267 (2013.01); A61B 5/742 (2013.01); G06N 7/01 (2023.01); G06N 20/20 (2019.01); G16H 20/17 (2018.01)] 8 Claims
OG exemplary drawing
 
1. A method for generating a sedation level estimate, the method comprising:
receiving an electroencephalography (EEG) signal from a sensor electrode attached to a patient, the EEG signal comprising a plurality of channels;
segmenting the EEG signal into smaller epochs for each channel;
extracting features of the EEG signal in each epoch, the features comprising time domain features, frequency domain features, and entropy domain features;
determining a median of features among the plurality of channels for each epoch;
determining, by a classifier, a probabilistic estimate of a patient sedation, wherein the classifier is trained using training data comprising MOAA/S scores, the training data selected to exclude MOAA/S scores in a center range of the MOAA/S scores;
generating, using a determined correlation, a sedation level estimate, the sedation level estimate comprising a continuous sedation score; and
displaying an indication of the sedation level estimate.