US 12,076,143 B2
Wearable biosensors with room temperature ionic liquid buffer
Shalini Prasad, Allen, TX (US); and Sriram Muthukumar, Allen, TX (US)
Assigned to EnLiSense, LLC, Allen, TX (US); and Board of Regents, The University of Texas System, Austin, TX (US)
Filed by EnLiSense LLC, Allen, TX (US); and Board of Regents, The University of Texas System, Austin, TX (US)
Filed on Sep. 6, 2018, as Appl. No. 16/124,164.
Claims priority of provisional application 62/554,841, filed on Sep. 6, 2017.
Claims priority of provisional application 62/554,956, filed on Sep. 6, 2017.
Prior Publication US 2019/0069818 A1, Mar. 7, 2019
Int. Cl. A61B 5/1477 (2006.01); A61B 5/145 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/1477 (2013.01) [A61B 5/14517 (2013.01); A61B 5/0002 (2013.01); A61B 5/6833 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An apparatus comprising:
a porous substrate having a first surface and an opposing second surface, the second surface to contact a subject to absorb fluid carrying an analyte from the subject;
a layer of semiconducting oxide coated on a portion of the first surface, the semiconducting oxide functionalized to conjugate with the analyte;
two or more electrodes attached to the first surface of the porous substrate and in direct contact with the layer of semiconducting oxide; and
a Room-Temperature Ionic Liquid (RTIL) between the first surface and the second surface, wherein:
the layer of semiconducting oxide is in direct contact with the RTIL and the electrodes,
the RTIL does not contain elements that bind with the analyte, and
the RTIL is to contain the fluid carrying the analyte between the first surface and the second surface for measurement by the electrodes.