US 12,076,138 B2
Ultrasound-guided optoacoustic monitoring of oxygen saturation
Donald S. Prough, Galveston, TX (US); Michael P Kinsky, League City, TX (US); Rinat O. Esenaliev, Galveston, TX (US); Irene Y. Petrov, Galveston, TX (US); and Yuriy Petrov, Galveston, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Appl. No. 16/332,538
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Sep. 12, 2017, PCT No. PCT/US2017/051217
§ 371(c)(1), (2) Date Mar. 12, 2019,
PCT Pub. No. WO2018/049415, PCT Pub. Date Mar. 15, 2018.
Claims priority of provisional application 62/393,520, filed on Sep. 12, 2016.
Prior Publication US 2019/0231239 A1, Aug. 1, 2019
Int. Cl. A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 8/00 (2006.01); A61B 8/08 (2006.01)
CPC A61B 5/14542 (2013.01) [A61B 5/0095 (2013.01); A61B 5/145 (2013.01); A61B 8/0891 (2013.01); A61B 8/4281 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for ultrasound guided optoacoustic measurement of blood oxygenation in a blood vessel comprising:
applying an ultrasound probe to a sternal notch of a patient to thereby localize a left innominate vein,
applying an optoacoustic system to stimulate the localized innominate vein, wherein the optoacoustic system comprises an optoacoustic stimulus and an optoacoustic probe,
applying the optoacoustic system to the stimulated left innominate vein to detect optoacoustic signals, and
approximating blood oxygenation at a central vena cava by quantitatively determining blood oxygenation in venous blood from the detected optoacoustic signals.