US 12,076,128 B2
Methods of evaluating cerebrovascular reactivity using transcranial doppler
Mohammed Alwatban, Riyadh (SA); and Gregory R. Bashford, Lincoln, NE (US)
Assigned to NUtech Ventures, Lincoln, NE (US)
Filed by NUtech Ventures, Lincoln, NE (US)
Filed on Mar. 15, 2020, as Appl. No. 16/819,140.
Claims priority of provisional application 62/819,200, filed on Mar. 15, 2019.
Prior Publication US 2020/0288994 A1, Sep. 17, 2020
Int. Cl. A61B 5/0285 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/021 (2006.01); A61B 5/08 (2006.01); A61B 5/087 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01)
CPC A61B 5/0285 (2013.01) [A61B 5/0205 (2013.01); A61B 5/02133 (2013.01); A61B 5/082 (2013.01); A61B 5/087 (2013.01); A61B 5/4088 (2013.01); A61B 5/4836 (2013.01); C07K 16/28 (2013.01); A61K 38/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of detecting compromised cerebrovascular reactivity in a subject, comprising the steps of:
acquiring a set of transcranial Doppler signals from a subject during performance of a breath-hold maneuver by the subject and calculating cerebral blood flow velocity (CBFV) measurements in response to the set of transcranial Doppler signals;
acquiring a set of cardiac measurements of the subject during performance of the breath-hold maneuver, wherein the set of cardiac measurements include systolic velocity (Vs) and diastolic velocity (Vd) in each cardiac cycle for cardiac cycles during the breath-hold maneuver;
calculating, using a processor executing computer-readable instructions, a mean velocity by averaging the CBFV measurements within each cardiac cycle;
calculating, using the processor executing computer-readable instructions, a breath-hold acceleration index of the subject based on a linear regression correlation of temporal variations of the mean velocity across all cardiac cycles during the breath-hold maneuver;
detecting presence of compromised cerebrovascular reactivity in the subject in response to the breath-hold acceleration index of the subject being more than one standard deviation less than a breath-hold acceleration index of a healthy individual performing the breath-hold maneuver under similar conditions as the subject; and
administering a therapeutically effective compound or providing a behavioral modification regimen to the subject in response to detecting compromised cerebrovascular reactivity in the subject.