US 12,722,012 B2
Closed-loop deep brain stimulation (DBS) programming based on evoked signals and local field potential (LFP) signals
Kristin N. Hageman, Dayton, MN (US); Scott R. Stanslaski, Shoreview, MN (US); Erik J. Peterson, Fridley, MN (US); Rene A. Molina, Maple Grove, MN (US); Paul H. Stypulkowski, North Oaks, MN (US); David A. Dinsmoor, North Oaks, MN (US); and Leonid M. Litvak, Beit Shemesh (IL)
Assigned to Medtronic, Inc., Minneapolis, MN (US)
Filed by Medtronic, Inc., Minneapolis, MN (US)
Filed on Apr. 26, 2023, as Appl. No. 18/307,585.
Claims priority of provisional application 63/363,984, filed on May 2, 2022.
Prior Publication US 2023/0347152 A1, Nov. 2, 2023
Int. Cl. A61N 1/36 (2006.01); A61N 1/02 (2006.01)
CPC A61N 1/36139 (2013.01) [A61N 1/025 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A system for closed-loop therapy, the system comprising:
memory configured to store a first set of one or more parameters for a first set of one or more therapeutic electrical stimulation signals; and
processing circuitry coupled to the memory and configured to:
determine one or more local field potential (LFP) measurements of an LFP, wherein the LFP is of a first signal type that is intrinsically generated by a signal source within a brain of a patient;
cause delivery of one or more electrical stimulation signals;
determine one or more evoked signals that are evoked by delivery of respective ones of the one or more electrical stimulation signals, wherein the one or more evoked signals are of a second signal type that is different than the first signal type of the LFP;
determine a second set of one or more parameters for a second set of one or more therapeutic electrical stimulation signals based on the one or more evoked signals having the second signal type and the one or more LFP measurements of the LFP having the first signal type, wherein the second set of one or more parameters are updates to the first set of one or more parameters; and
cause delivery of the second set of the one or more therapeutic electrical stimulation signals.