US 12,721,685 B2
Use of evoked potentials in deep brain stimulation neuromodulation
G. Karl Steinke, Valencia, CA (US); and Mahsa Malekmohammadi, Sherman Oaks, CA (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Mar. 5, 2025, as Appl. No. 19/071,353.
Claims priority of provisional application 63/570,457, filed on Mar. 27, 2024.
Prior Publication US 2025/0302544 A1, Oct. 2, 2025
Int. Cl. A61N 1/05 (2006.01); A61B 34/00 (2016.01); A61B 34/20 (2016.01); A61N 1/08 (2006.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01)
CPC A61B 34/20 (2016.02) [A61B 34/25 (2016.02); A61N 1/0534 (2013.01); A61N 1/08 (2013.01); A61N 1/36135 (2013.01); A61N 1/37241 (2013.01); A61B 2034/2053 (2016.02)] 20 Claims
OG exemplary drawing
 
1. A method of estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the method comprising:
using one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
using at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
comparing the first EPs and the second EPs to determine a delay between the EPs wherein the delay is indicative a difference in a number or kind of synapses between a first neural circuit giving rise to the first EP and a second neural circuit giving rise to the second EP; and
using the comparison to estimate a location of the electrode lead within the patient's brain.
 
9. A system for estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the system comprising:
control circuitry configured to:
use one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
use at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
compare the first EPs and the second EPs to determine a delay between the EPs wherein the delay is indicative a difference in a number or kind of synapses between a first neural circuit giving rise to the first EP and a second neural circuit giving rise to the second EP; and
use the comparison to estimate a location of the electrode lead within the patient's brain.
 
17. A method of estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the method comprising:
using one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
using at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
comparing the first EPs and the second EPs to determine if the first and second electrodes are concurrently in different anatomical brain structures; and
using the comparison to estimate a location of the electrode lead within the patient's brain.