	US RE50,566 E1
	Compositions and methods for modulating neuronal excitability and motor behavior
Anne Schaefer, New York, NY (US); Paul Greengard, New York, NY (US); and Chan Lek Tan, San Francisco, CA (US)
Assigned to Icahn School of Medicine at Mount Sinai, New York, NY (US)
Appl. No. 17/665,111
Filed by Icahn School of Medicine at Mount Sinai, New York, NY (US); and The Rockefeller University, New York, NY (US)
PCT Filed Oct. 28, 2014, PCT No. PCT/US2014/062664 § 371(c)(1), (2) Date Apr. 26, 2016, PCT Pub. No. WO2015/066034, PCT Pub. Date May 7, 2015.
Application 17/665,111 is a reissue of application No. 15/032,255, filed on Oct. 28, 2014, granted, now 10,087,443, issued on Oct. 2, 2018.
Claims priority of provisional application 61/896,463, filed on Oct. 28, 2013.
Claims priority of provisional application 61/898,952, filed on Nov. 1, 2013.
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/113 (2010.01); A01K 67/0275 (2024.01); A01K 67/0276 (2024.01); A61K 38/18 (2006.01)

CPC C12N 15/113 (2013.01) [A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); A61K 38/185 (2013.01)]

3 Claims

1. A method for treating or reducing the likelihood of the development or occurrence of seizures in an individual with Dravet Syndrome, comprising administering to said individual a therapeutically effective amount of microRNA-128 (miR-128) having the nucleotide sequence of SEQ ID NO: 1 [ , wherein the administering the therapeutically effective amount of miR-128 does not comprise administering miR-128-expressing cells] .