| CPC G06T 11/005 (2013.01) [A61B 6/037 (2013.01); A61B 6/503 (2013.01); A61B 6/5217 (2013.01); A61B 6/5264 (2013.01); A61B 6/5288 (2013.01); G06T 3/147 (2024.01); G06T 11/008 (2013.01); G06T 2210/41 (2013.01)] | 17 Claims |

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1. A computer-implemented method for motion compensation of medical imaging data, comprising:
estimating, via a processor, non-periodic motion of a myocardium of a heart due to respiration and/or other body movements throughout a positron emission tomography (PET) scan based on list-mode emission data acquired during the PET scan of the heart of a subject; and
performing, via the processor, event-by-event motion-corrected list-mode reconstruction on the list-mode emission data to generate cardiac images with the non-periodic motion removed, wherein performing the event-by-event motion-corrected list-mode reconstruction on the list-mode emission data comprises performing cardiac-gated reconstruction on the list-mode emission data to generate cardiac-gated images with the non-periodic motion removed, wherein performing the event-by-event motion-corrected list mode cardiac-gated reconstruction comprises:
performing, via the processor, motion correction on each event of the list-mode emission data; and
performing, via the processor, cardiac-gated reconstruction on the motion-corrected list-mode emission data; and
wherein performing motion correction on each event comprises:
repositioning, via the processor, the endpoints of each event to account for motion at a corresponding time point; and
calculating, via the processor, motion-aware corrections.
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