US 12,406,365 B2
Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
James K. Min, Chapel Hill, NC (US); James P. Earls, Alexandria, VA (US); Shant Malkasian, Pasadena, CA (US); Hugo Miguel Rodrigues Marques, Lisbon (PT); Chung Chan, Northbrook, IL (US); and Shai Ronen, Westminster, CO (US)
Assigned to Cleerly, Inc., Denver, CO (US)
Filed by Cleerly, Inc., Denver, CO (US)
Filed on Mar. 7, 2023, as Appl. No. 18/179,921.
Claims priority of provisional application 63/381,210, filed on Oct. 27, 2022.
Claims priority of provisional application 63/368,293, filed on Jul. 13, 2022.
Claims priority of provisional application 63/365,381, filed on May 26, 2022.
Claims priority of provisional application 63/364,084, filed on May 3, 2022.
Claims priority of provisional application 63/364,078, filed on May 3, 2022.
Claims priority of provisional application 63/362,856, filed on Apr. 12, 2022.
Claims priority of provisional application 63/362,108, filed on Mar. 29, 2022.
Claims priority of provisional application 63/269,136, filed on Mar. 10, 2022.
Prior Publication US 2023/0289963 A1, Sep. 14, 2023
Int. Cl. G06T 7/12 (2017.01); A61B 5/00 (2006.01); G06T 7/00 (2017.01); G06T 7/62 (2017.01)
CPC G06T 7/0012 (2013.01) [A61B 5/7275 (2013.01); G06T 7/62 (2017.01); G06T 2207/10048 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10101 (2013.01); G06T 2207/10104 (2013.01); G06T 2207/10108 (2013.01); G06T 2207/10116 (2013.01); G06T 2207/10132 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/30101 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A computer-implemented method of determination of fractional flow reserve and assessment of ischemia based at least in part on one or more measurements derived from non-invasive medical image analysis, the computer-implemented method comprising:
accessing, by a computer system, a medical image of a subject, wherein the medical image of the subject is obtained non-invasively;
analyzing, by the computer system, the medical image of the subject to identify one or more coronary arteries;
determining, by the computer system, one or more stenosis measurements based on analysis of the identified one or more coronary arteries in the medical image of the subject, the one or more stenosis measurements comprising coronary lumen area (A) and subtended myocardial mass (M);
determining, by the computer system, non-invasive fractional flow reserve (FFRnon-invasive) for the identified one or more coronary arteries based at least in part by applying the one or more stenosis measurements to

OG Complex Work Unit Math
 wherein Y0 comprises a constant, and wherein bA and bM comprise exponential coefficients; and
generating, by the computer system, an assessment of ischemia based at least in part on the determined non-invasive fractional flow reserve for the identified one or more coronary arteries,
wherein the computer system comprises a computer processor and an electronic storage medium.