US 12,405,281 B1
Method and kit for monitoring anticoagulant therapy
Pall T. Onundarson, Gardabaer (IS); and Brynja R. Gudmundsdottir, Reykjavik (IS)
Assigned to FIIX DIAGNOSTICS, Gardabaer (IS)
Filed by FIIX DIAGNOSTICS, Gardabaer (IS)
Filed on Sep. 3, 2024, as Appl. No. 18/823,356.
Claims priority of provisional application 63/683,855, filed on Aug. 16, 2024.
Claims priority of provisional application 63/560,939, filed on Mar. 4, 2024.
Int. Cl. G01N 33/86 (2006.01)
CPC G01N 33/86 (2013.01) [G01N 2333/96463 (2013.01)] 23 Claims
 
1. A method for measuring an effect of an anticoagulant drug in a patient, the effect being based on measuring, in a test sample from the patient, an influence of said anticoagulant drug on combined activity of only coagulation factors II and X, the method comprising:
mixing a plasma reagent that has been made deficient in only factors II, IX, and X into the test sample to create a corrected test sample;
adding one or more coagulation reagents that activates factor VII or factor X but not factor IX, bypassing activation of factor IX; and
determining blood clotting ability of the corrected test sample by measuring blood clotting time or thrombin generation.