US 12,405,260 B2
Multiplexed detection of toxins using graphene-based aptasensors
Alan T. Johnson, Jr., Philadelphia, PA (US); Jinglei Ping, Gaithersburg, MD (US); Steven Vitale, Collingswood, NJ (US); and Chengyu Wen, Philadelphia, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Nov. 8, 2023, as Appl. No. 18/504,369.
Application 18/504,369 is a continuation of application No. 16/299,615, filed on Mar. 12, 2019, granted, now 11,846,622.
Claims priority of provisional application 62/641,476, filed on Mar. 12, 2018.
Prior Publication US 2024/0319160 A1, Sep. 26, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/18 (2006.01); G01N 27/04 (2006.01)
CPC G01N 33/1813 (2013.01) [G01N 27/04 (2013.01); G01N 33/1826 (2013.01); G01N 2410/00 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A sensor device, comprising:
a portion of graphene and/or graphene oxide in electronic communication with a gold source electrode, a drain electrode, a gate electrode, or any combination thereof, and
an aptamer in electrical communication with the portion of graphene and/or graphene oxide,
the portion of graphene and/or graphene oxide connected to said aptamer via at least one linker that comprises 4-carboxybenzenediazonium tetrafluoroborate.