	US 12,404,540 B2
	Epigenetic biomarker and uses therefor
Abu Sina, St Lucia (AU); Matt Trau, St Lucia (AU); and Laura Garcia Carrascosa, St Lucia (AU)
Assigned to THE UNIVERSITY OF QUEENSLAND, St Lucia (AU)
Appl. No. 17/286,379
Filed by THE UNIVERSITY OF QUEENSLAND, St Lucia (AU)
PCT Filed Oct. 17, 2019, PCT No. PCT/AU2019/051131 § 371(c)(1), (2) Date Apr. 16, 2021, PCT Pub. No. WO2020/077409, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 2018903935 (AU), filed on Oct. 17, 2018.
Prior Publication US 2022/0033880 A1, Feb. 3, 2022
Int. Cl. C12Q 1/6809 (2018.01); C12Q 1/6886 (2018.01)

CPC C12Q 1/6809 (2013.01) [C12Q 1/6886 (2013.01); C12Q 2600/154 (2013.01)]

9 Claims

1. A method for detecting and measuring cancer DNA, the method comprising:

exposing endogenous cancer DNA from a biological sample to a working electrode that comprises an electro-conductive material;

applying a potential to the working electrode; and

detecting an electrical signal from the working electrode that is indicative of adsorption of the endogenous cancer DNA to the electro-conductive material, wherein the electrical signal from the working electrode is different than another electrical signal generated from the working electrode when exposed to (1) one corresponding non-cancer DNA or (2) a total amount of endogenous cancer DNA from another biological sample that is different than a total amount of the endogenous cancer DNA from the biological sample.