US 12,404,523 B2
Adeno-associated virus delivery of CLN3 polynucleotide
Kathrin Meyer, Columbus, OH (US); Brian K. Kaspar, Columbus, OH (US); and Kevin Foust, Columbus, OH (US)
Assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US); and OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Appl. No. 17/427,010
Filed by RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US); and OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
PCT Filed Feb. 4, 2020, PCT No. PCT/US2020/016542
§ 371(c)(1), (2) Date Jul. 29, 2021,
PCT Pub. No. WO2020/163300, PCT Pub. Date Aug. 13, 2020.
Claims priority of provisional application 62/800,911, filed on Feb. 4, 2019.
Prior Publication US 2022/0127641 A1, Apr. 28, 2022
Int. Cl. C12N 15/86 (2006.01); A61P 3/00 (2006.01); A61P 25/00 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01)
CPC C12N 15/86 (2013.01) [A61P 3/00 (2018.01); A61P 25/00 (2018.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01)] 26 Claims
 
1. A nucleic acid molecule comprising at least 90% sequence similarity to the nucleic acid sequence of SEQ ID NO: 4.