	US 12,404,511 B2
	UV-resistant biological devices and extracts and methods for producing and using the same
Raul Cuero Rengifo, Cypress, TX (US)
Assigned to BIOCAPITAL HOLDINGS, LLC, Houston, TX (US)
Filed by Bio Capital Holdings, LLC, Houston, TX (US)
Filed on Mar. 21, 2023, as Appl. No. 18/187,249.
Application 18/187,249 is a continuation of application No. 16/686,326, filed on Nov. 18, 2019, granted, now 11,639,505.
Application 16/686,326 is a continuation in part of application No. PCT/US2018/033090, filed on May 17, 2018.
Claims priority of provisional application 62/557,217, filed on Sep. 12, 2017.
Claims priority of provisional application 62/507,946, filed on May 18, 2017.
Prior Publication US 2024/0209380 A1, Jun. 27, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/64 (2006.01); C12N 9/04 (2006.01); C12N 9/12 (2006.01)

CPC C12N 15/64 (2013.01) [C12N 9/0006 (2013.01); C12N 9/1205 (2013.01); C12N 2800/10 (2013.01)]

18 Claims

1. A topical composition comprising an extract comprising hexokinase, a heat shock protein, and an alcohol dehydrogenase, wherein the heat shock protein is HSP70, and wherein the extract is produced by culturing a biological device comprising host cells transformed with a vector, wherein culturing is conducted under exposure to UV radiation, and wherein the vector comprises a DNA construct comprising the following genetic components:

(a) a gene having SEQ ID NO: 4 or at least 90% homology thereto that encodes the hexokinase;

(b) a gene having SEQ ID NO: 5 or at least 90% homology thereto that encodes the heat shock protein;