US 12,404,367 B2
Degradable multi-arm polyethylene glycol derivative
Hiroki Yoshioka, Kawasaki (JP); Ken Hamura, Kawasaki (JP); Kazuki Osakama, Kawasaki (JP); and Nobuhiro Nishiyama, Tokyo (JP)
Assigned to NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
Appl. No. 17/763,498
Filed by NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
PCT Filed Sep. 25, 2020, PCT No. PCT/JP2020/036197
§ 371(c)(1), (2) Date Mar. 24, 2022,
PCT Pub. No. WO2021/060441, PCT Pub. Date Apr. 1, 2021.
Claims priority of application No. 2019-176230 (JP), filed on Sep. 26, 2019.
Prior Publication US 2022/0380533 A1, Dec. 1, 2022
Int. Cl. C08G 65/333 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01); C07K 14/46 (2006.01); C08G 83/00 (2006.01)
CPC C08G 65/333 (2013.01) [C07K 5/1008 (2013.01); C07K 7/06 (2013.01); C07K 14/46 (2013.01); C08G 83/003 (2013.01)] 15 Claims
 
1. A degradable polyethylene glycol derivative represented by the following formula (1):

OG Complex Work Unit Chemistry
wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.