	US 12,404,347 B2
	Glucuronoxylomannan (GXM) receptor chimeric antigen receptors and use thereof
Pappanaicken Kumar, Houston, TX (US); Thiago Aparecido Da Silva, Houston, TX (US); and Paul J. Hauser, Houston, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/429,090
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Feb. 7, 2020, PCT No. PCT/US2020/017156 § 371(c)(1), (2) Date Aug. 6, 2021, PCT Pub. No. WO2020/163682, PCT Pub. Date Aug. 13, 2020.
Claims priority of provisional application 62/802,532, filed on Feb. 7, 2019.
Prior Publication US 2022/0106407 A1, Apr. 7, 2022
Int. Cl. C07K 16/44 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/44 (2025.01); A61K 45/06 (2006.01); A61P 31/10 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01)

CPC C07K 16/44 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/44 (2025.01); A61K 45/06 (2013.01); A61P 31/10 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C12N 5/0636 (2013.01); A61K 2239/17 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01)]

13 Claims

1. A chimeric antigen receptor (CAR) comprising (a) a glucuronoxylomannan (GXM) scFv comprising an amino acid sequence of SEQ ID NO: 2, (b) signaling domains CD3ξ, CD28, OX40/CD134, 4-1BB/CD137, TRAM, MyD88, TRAF 6, pattern recognition receptor family member, Toll-like-receptor (TLR) family member or a combination thereof, and (c) a CD28, CD8α, CD134, CD137, pattern recognition receptor (PRR) or TLR transmembrane domain.