US 12,404,302 B2
Insect neuropeptides 6
Julian A. T. Dow, East Dunbartonshire (GB); Shireen A. Davies, East Dunbartonshire (GB); Yousef Abul-Haija, East Dunbartonshire (GB); and Lewis Archibald, Glasgow (GB)
Assigned to Solasta Bio Limited, Glasgow (GB)
Filed by Solasta Bio Limited, Glasgow (GB)
Filed on Oct. 10, 2024, as Appl. No. 18/912,061.
Application 18/912,061 is a division of application No. 18/491,976, filed on Oct. 23, 2023, granted, now 12,139,556.
Claims priority of application No. 2215797 (GB), filed on Oct. 25, 2022.
Prior Publication US 2025/0042945 A1, Feb. 6, 2025
Int. Cl. C07K 7/06 (2006.01); A01N 37/46 (2006.01); A01P 7/04 (2006.01)
CPC C07K 7/06 (2013.01) [A01N 37/46 (2013.01); A01P 7/04 (2021.08)] 7 Claims
 
1. An insecticidal compound having the formula (I) below, or a salt or solvate thereof:
R1—Y1—Z—Y2—R2  (I)
wherein:
R1 is hydrogen, C1-4alkyl (e.g. methyl, ethyl, propyl, butyl), formyl, acyl, fatty acyl, a sugar moiety, phosphate or sulphate, or R1 is a pyroglutamate group of the formula:

OG Complex Work Unit Chemistry
and any alkyl, formyl, acyl or fatty acyl may optionally be substituted with one or more groups selected from oxo or C1-6alkyl, or a sugar moiety, phosphate or sulphate;
Y1 is absent or is a peptide comprising from 1 to 2 amino acids;
Z is a peptide according to formula:
RQKTVFSSWG (SEQ ID NO:1);
Y2 is absent or is a peptide comprising from 1 to 2 amino acids;
R2 is NH2, NR2aH, NR2aR2b, or OR2a, wherein each of R2a and R2b if present are independently C1-6-alkyl.