US 12,404,282 B2
Process for the purification of indole carbazole alkaloids
Katia Miele, Milan (IT); Luca Domenighini, Milan (IT); and Daniele Ciceri, Milan (IT)
Assigned to INDENA S.P.A., Milan (IT)
Appl. No. 17/905,327
Filed by INDENA S.P.A., Milan (IT)
PCT Filed Mar. 1, 2021, PCT No. PCT/IB2021/051683
§ 371(c)(1), (2) Date Aug. 30, 2022,
PCT Pub. No. WO2021/176328, PCT Pub. Date Sep. 10, 2021.
Claims priority of application No. 102020000004291 (IT), filed on Mar. 2, 2020.
Prior Publication US 2023/0128149 A1, Apr. 27, 2023
Int. Cl. C07D 498/22 (2006.01)
CPC C07D 498/22 (2013.01) 13 Claims
 
1. A process for the purification of staurosporine (1), which comprises salification of staurosporine (1)

OG Complex Work Unit Chemistry
by treatment with a mineral acid to give a precipitated salt, isolation of the precipitated salt of staurosporine (1), treatment of the isolated salt of staurosporine (1) with an organic base selected from ammonia, primary, secondary, tertiary aliphatic amine or primary, secondary, tertiary aromatic amine, and isolation of staurosporine (1).