	US 12,404,253 B2
	2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1
Karolina Nilsson, Sodertalje (SE); Martin Bauer, Sodertalje (SE); Maria Olwegard Halvarsson, Sodertalje (SE); Mikael Brink, Sodertalje (SE); and Fredrik Bergström, Sodertalje (SE)
Filed by ASTRAZENECA AB, Sodertalje (SE)
Filed on Jul. 24, 2024, as Appl. No. 18/783,231.
Application 18/783,231 is a continuation of application No. 18/489,184, filed on Oct. 18, 2023.
Claims priority of provisional application 63/417,472, filed on Oct. 19, 2022.
Prior Publication US 2024/0383866 A1, Nov. 21, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 251/18 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 405/10 (2006.01); C07D 413/06 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01)

CPC C07D 251/18 (2013.01) [C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 405/10 (2013.01); C07D 413/06 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01)]

30 Claims

1. A compound selected from N-(4-((R)-2-(2,3-Difluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-((S)-2-(2,3-Difluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide:

or a pharmaceutically acceptable salt thereof.

11. A compound selected from N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-((R)-2-(6-methoxypyridin-3yl)propyl)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-((S)-2-(6-methoxypyridin-3yl)propyl)-1,3,5-triazin-2-yl)methanesulfonamide:

or a pharmaceutically acceptable salt thereof.

21. A compound selected from N-(4-((R)-2-(5-Fluoro-6-methoxypyridin-3-yl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-((S)-2-(5-Fluoro-6-methoxypyridin-3-yl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide:

or a pharmaceutically acceptable salt thereof.