US 12,404,246 B1
2-aminomethylimidazole mimics of NS4A and their effect thereof on hepatitis C virus NS3 protease
Mohammed A. Baradwan, Jeddah (SA); Abdelsattar M. Omar, Jeddah (SA); Mahmoud A. Elfaky, Jeddah (SA); Moustafa E. El-Araby, Cairo Governorate (EG); and Sameh H. Soror, Cairo Governorate (EG)
Assigned to King Abdulaziz University, Jeddah (SA)
Filed by Mohammed A. Baradwan, Jeddah (SA); Abdelsattar M. Omar, Jeddah (SA); Mahmoud A. Elfaky, Jeddah (SA); Moustafa E. El-Araby, Cairo Governorate (EG); and Sameh H. Soror, Cairo Governorate (EG)
Filed on Oct. 1, 2024, as Appl. No. 18/903,487.
Int. Cl. C07D 233/90 (2006.01); A61K 31/4164 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01)
CPC C07D 233/90 (2013.01) [A61K 31/4164 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01)] 10 Claims
 
1. A compound of formula (I)

OG Complex Work Unit Chemistry
or a salt thereof, a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof;
wherein:
C2-C8 alkyl optionally substituted with at least one substituent selected from the group consisting of an alkyloxy, a cycloalkyloxy, an aryloxy, an amine, and an amide,
X is selected from the group consisting of NH or O R2 is selected from the group consisting of H, alkyl, aralkyl, C1-C10 heteroalkyl, heteroarylalkyl, or heterocyclic, wherein said C1-C10 heteroalkyl comprises up to 10 heteroatoms selected from the group consisting of nitrogen, oxygen or sulfur, and the alkyl moiety of the C1-C10 heteroalkyl group may be in a linear, branched or cyclic arrangement, and R3 is selected is from the group consisting of heteroalkyl, heteroarylalkyl or heterocyclic.