US 12,404,243 B2
Inhibitors of the Wnt/beta-catenin pathway
Michael E. Jung, Los Angeles, CA (US); Xiaohong Chen, Los Angeles, CA (US); Cun-Yu Wang, Los Angeles, CA (US); Jiong Li, Van Nuys, CA (US); and Jie Zheng, Los Angeles, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Mar. 24, 2023, as Appl. No. 18/125,961.
Application 18/125,961 is a continuation of application No. 16/962,751, granted, now 11,708,329, previously published as PCT/US2019/015875, filed on Jan. 30, 2019.
Claims priority of provisional application 62/623,976, filed on Jan. 30, 2018.
Prior Publication US 2024/0059654 A1, Feb. 22, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 295/16 (2006.01); A61P 35/00 (2006.01); C07C 235/62 (2006.01); C07C 237/04 (2006.01); C07C 237/38 (2006.01); C07C 311/07 (2006.01); C07D 211/86 (2006.01); C07D 213/06 (2006.01); C07D 213/38 (2006.01); C07D 213/40 (2006.01); C07D 213/50 (2006.01); C07D 213/55 (2006.01); C07D 213/68 (2006.01); C07D 213/89 (2006.01); C07D 295/088 (2006.01); C07D 295/135 (2006.01); C07D 295/15 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01)
CPC C07D 213/68 (2013.01) [A61P 35/00 (2018.01); C07C 235/62 (2013.01); C07C 237/04 (2013.01); C07C 237/38 (2013.01); C07C 311/07 (2013.01); C07D 211/86 (2013.01); C07D 213/06 (2013.01); C07D 213/38 (2013.01); C07D 213/40 (2013.01); C07D 213/50 (2013.01); C07D 213/55 (2013.01); C07D 213/89 (2013.01); C07D 295/088 (2013.01); C07D 295/135 (2013.01); C07D 295/15 (2013.01); C07D 295/16 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01)] 16 Claims
 
1. A compound having a structure represented by Formula Ib or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein
R4 is substituted alkenyl, substituted acyl, substituted C(O)alkyl, substituted C(O)Oalkyl, substituted C(O)Oaryl, substituted C(O)Oheteroaryl, substituted C(O)N(R5aR5b), or substituted alkylsulfonyl, further wherein each substituted alkenyl, substituted acyl, substituted C(O)alkyl, substituted C(O)Oalkyl, substituted C(O)Oaryl, substituted C(O)Oheteroaryl, substituted C(O)N(R5aR5b), or substituted alkylsulfonyl is substituted with at least one basic nitrogen; and
R5a and R5b are each independently hydrogen, alkyl, or aryl.