US 12,404,226 B2
Method for addition reaction of acetylene and ketone compound
Hao Hong, Morrisville, NC (US); Jiangping Lu, Tianjin (CN); Xichun Feng, Tianjin (CN); Xin Zhang, Tianjin (CN); and Bo Yan, Tianjin (CN)
Assigned to ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD., Tianjin (CN)
Appl. No. 17/642,937
Filed by ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD., Tianjin (CN)
PCT Filed Sep. 17, 2019, PCT No. PCT/CN2019/106220
§ 371(c)(1), (2) Date Mar. 14, 2022,
PCT Pub. No. WO2021/051275, PCT Pub. Date Mar. 25, 2021.
Prior Publication US 2022/0380280 A1, Dec. 1, 2022
Int. Cl. C07C 29/42 (2006.01); B01J 10/00 (2006.01); B01J 19/00 (2006.01); B01J 19/24 (2006.01); C07C 29/38 (2006.01); C07C 41/48 (2006.01)
CPC C07C 29/42 (2013.01) [B01J 10/002 (2013.01); B01J 19/0013 (2013.01); B01J 19/242 (2013.01); C07C 29/38 (2013.01); C07C 41/48 (2013.01); B01J 2219/00033 (2013.01); B01J 2219/00094 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for addition reaction of acetylene and a ketone compound, comprising the steps of:
S1, providing a continuous reaction device, the continuous reaction device comprising a plurality of bubble tubular reactors arranged in series, the plurality of bubble tubular reactors being connected with each other through connecting tubes;
S2, feeding a raw material solution containing the ketone compound and alkali into the plurality of bubble tubular reactors, and
S3, under normal pressure, pumping acetylene from the bottom of the first bubble tubular reactor for the addition reaction.