US 12,404,184 B2
Method for continuous growth of water-soluble magnetic nanomaterials
Yongfeng Zhao, Edwardsville, IL (US)
Assigned to Jackson State University, Jackson, MS (US)
Filed by Jackson State University, Jackson, MS (US)
Filed on Feb. 19, 2020, as Appl. No. 16/795,414.
Claims priority of provisional application 62/807,407, filed on Feb. 19, 2019.
Prior Publication US 2020/0262715 A1, Aug. 20, 2020
Int. Cl. C01G 49/08 (2006.01); B82Y 40/00 (2011.01); C01G 49/00 (2006.01); H01F 1/36 (2006.01); B82Y 25/00 (2011.01)
CPC C01G 49/08 (2013.01) [C01G 49/0072 (2013.01); H01F 1/36 (2013.01); B82Y 25/00 (2013.01); B82Y 40/00 (2013.01); C01P 2002/72 (2013.01); C01P 2002/82 (2013.01); C01P 2002/88 (2013.01); C01P 2004/04 (2013.01); C01P 2004/64 (2013.01); C01P 2006/42 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for synthesizing water-soluble metal oxide nanoparticles, the method comprising:
a. heating a first reaction mixture at a first predetermined temperature for a first predetermined time duration with continuous stirring to obtain a second reaction mixture that comprises water-soluble metal oxide nanoparticles of a first size, the first size having a standard deviation of about 10%, and the first reaction mixture comprising a reactant and a polyol, wherein the polyol is diethylene glycol (DEG);
b. adding a first predetermined amount of the reactant to the second reaction mixture to obtain a third reaction mixture; and
c. heating the third reaction mixture at a second predetermined temperature for a second predetermined time duration with continuous stirring to obtain a fourth reaction mixture comprising water-soluble metal oxide nanoparticles of a second size, wherein the second predetermined temperature is greater than the first predetermined temperature,
wherein the water-soluble metal oxide nanoparticles having a size of around 9 nm exhibit a transversal relaxivity of around 425 mMol-1.s-1 and a longitudinal relaxivity of around 32 mMol-1.s-1.