US 12,403,452 B2
Stationary phase for chromatography
Kanji Nagai, Tokyo (JP); and Satoshi Shinkura, Tokyo (JP)
Assigned to DAICEL CORPORATION, Osaka (JP)
Appl. No. 17/271,688
Filed by DAICEL CORPORATION, Osaka (JP)
PCT Filed Aug. 30, 2019, PCT No. PCT/JP2019/034204
§ 371(c)(1), (2) Date Feb. 26, 2021,
PCT Pub. No. WO2020/045648, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. 2018-161561 (JP), filed on Aug. 30, 2018.
Prior Publication US 2021/0252479 A1, Aug. 19, 2021
Int. Cl. B01J 20/285 (2006.01); B01D 15/40 (2006.01); B01J 20/30 (2006.01); C08F 2/44 (2006.01); C08F 222/38 (2006.01)
CPC B01J 20/285 (2013.01) [B01D 15/40 (2013.01); B01J 20/30 (2013.01); C08F 2/44 (2013.01); C08F 222/38 (2013.01)] 16 Claims
 
1. A stationary phase for chromatography, comprising inorganic carrier particles to which is bonded a polymer having a hydrophilic group on repeating units of a main chain thereof,
wherein the stationary phase has a structure represented by Formula (II):

OG Complex Work Unit Chemistry
wherein in Formula (II), W′ is a single bond or an alkylene group of 1 to 10 carbon atoms which may have a branched chain; W″ is hydrogen or an alkyl group of 1 to 12 carbon atoms; X is an amide group, an ester group, an N-alkylamide group of 1 to 3 carbon atoms, an ether group, a sulfoxide group, a sulfone group, a sulfide group, or a phosphate ester group; Y is an alkylene group of 1 to 30 carbon atoms; V is an ether group bonded to the inorganic carrier surface, an alkoxy group of 1 to 5 carbon atoms, halogen, alkylmercaptyl groups of 1 to 20 carbon atoms, nitrogen-containing groups, an allyl group, or a 2-methyl-2-propenyl group; Rt is hydrogen or an alkyl of 1 to 6 carbon atoms; R2 is a single bond or an alkylene of 1 to 12 carbon atoms; R3 is an alkylene of 1 to 6 carbon atoms; X2 is —O—, —NH—, or —N(CH3)—; Y2 is —PO4—, —N+H2—, —N+(R4)2—, or (—(CH2)a—O-)b, a is an integer of 1 to 5, and b is an integer of 1 to 20; Z2 is hydrogen, alkyl of 1 to 6 carbon atoms, halogen, —N+R34, —SO3—, —CO2—, or —PO4—R4; R4 is hydrogen, an alkyl of 1 to 6 carbon atoms, or a hydroxyalkyl of 1 to 6 carbon atoms; p is from 1 to 10; q is from 10 to 3000.