US 12,403,428 B2
Evaluation method for protein-containing solution
Takuma Iwasaki, Tokyo (JP); and Ryota Oguri, Tokyo (JP)
Assigned to ASAHI KASEI LIFE SCIENCE CORPORATION, Tokyo (JP)
Appl. No. 18/011,692
Filed by ASAHI KASEI LIFE SCIENCE CORPORATION, Tokyo (JP)
PCT Filed Jun. 21, 2021, PCT No. PCT/JP2021/023432
§ 371(c)(1), (2) Date Dec. 20, 2022,
PCT Pub. No. WO2021/261451, PCT Pub. Date Dec. 30, 2021.
Claims priority of application No. 2020-108837 (JP), filed on Jun. 24, 2020.
Prior Publication US 2023/0249135 A1, Aug. 10, 2023
Int. Cl. B01D 65/10 (2006.01); B01D 61/24 (2006.01); C07K 1/34 (2006.01); G01N 21/64 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01)
CPC B01D 65/109 (2022.08) [B01D 61/2461 (2022.08); C07K 1/34 (2013.01); G01N 21/64 (2013.01); G01N 33/543 (2013.01); G01N 33/68 (2013.01); B01D 2251/95 (2013.01); G01N 2333/908 (2013.01); G01N 2333/916 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for evaluating the clogging of a filtration membrane with a protein-containing solution, comprising the steps of:
a) passing a protein-containing solution through a filtration membrane,
b) after the step a), obtaining a filtration membrane cross-section from the filtration membrane,
c) treating the protein-containing solution before the step a), the filtration membrane before the step b), or the filtration membrane cross-section after the step b) with at least one stain specific to an aggregate of the protein, and
d) confirming the presence of the aggregate of the protein in the filtration membrane cross-section.