US 12,403,412 B2
Metal-organic frameworks for the removal of uremic toxins
Omar K. Farha, Glenview, IL (US); and Satoshi Kato, Fuji Shizuoka (JP)
Assigned to Northwestern University, Evanston, IL (US)
Appl. No. 17/286,986
Filed by Northwestern University, Evanston, IL (US)
PCT Filed Oct. 22, 2019, PCT No. PCT/US2019/057302
§ 371(c)(1), (2) Date Apr. 20, 2021,
PCT Pub. No. WO2020/086496, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/749,353, filed on Oct. 23, 2018.
Prior Publication US 2021/0387110 A1, Dec. 16, 2021
Int. Cl. B01J 20/22 (2006.01); B01D 15/08 (2006.01); B01J 20/28 (2006.01); C07F 5/00 (2006.01); C07F 7/00 (2006.01); G01N 1/34 (2006.01); G01N 1/40 (2006.01)
CPC B01D 15/08 (2013.01) [B01J 20/226 (2013.01); B01J 20/28057 (2013.01); B01J 20/2808 (2013.01); B01J 20/28083 (2013.01); C07F 5/003 (2013.01); C07F 7/003 (2013.01); G01N 1/34 (2013.01); G01N 1/405 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for removing uremic toxins from a sample, the method comprising:
exposing a sample comprising uremic toxins to a metal-organic framework consisting of: Zr6 nodes having hydroxyl groups thereon; and, linkers connecting the Zr6 nodes, the linkers consisting of tetratopic 3,3′,5,5′-tetrakis (4-carboxyphenyl)-1,1′-biphenyl linkers, wherein the metal-organic framework has a csq network topology and is designated NU-1010, wherein the uremic toxins have an aromatic ring and are bound to a protein, wherein the uremic toxins are adsorbed by the metal-organic framework; and removing the metal-organic framework and the adsorbed uremic toxins from the sample.