	US 12,403,334 B2
	Low intensity ultrasound therapy
Joseph Kost, Omer (IL); Aharon (Roni) Azagury, Kiryat Gat (IL); Yana Yudilevich, Beer Sheva (IL); Eden Bergman, Machane Adi (IL); Tamar Traitel, Beer Sheva (IL); Rivka Goldbart, Lehavim (IL); Itay Rousso, Even Yehuda (IL); and Moshe Elkabets, Kibbutz Beit Kama (IL)
Assigned to B G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, Beer Sheva (IL)
Filed by B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, Beer Sheva (IL)
Filed on Mar. 8, 2021, as Appl. No. 17/249,638.
Application 17/249,638 is a continuation in part of application No. 14/198,701, filed on Mar. 6, 2014, granted, now 10,960,233.
Claims priority of provisional application 61/773,169, filed on Mar. 6, 2013.
Prior Publication US 2021/0213307 A1, Jul. 15, 2021
Int. Cl. A61N 7/02 (2006.01); A61N 7/00 (2006.01)

CPC A61N 7/022 (2013.01) [A61N 2007/0004 (2013.01); A61N 2007/0073 (2013.01)]

7 Claims

1. A method of treating a subject suffering from a disease or a disorder associated with hyperproliferating cells, said method comprising non-invasively irradiating a tissue comprising said hyperproliferating cells in said subject with ultrasound, said ultrasound having a frequency between 20 and 200 kHz, at an intensity between 0.5 and 100 W/cm², provided that the intensity is characterized by a low-frequency mechanical index of between 1 and 2.5, wherein said intensity produces a mechanical index lower than 2.5, and wherein said method comprises evaluating a mechanical stiffness of said hyperproliferating cells, prior to said irradiating, and adjusting said intensity based on said evaluating.