| CPC A61N 5/1038 (2013.01) [A61N 5/1065 (2013.01); A61N 2005/1087 (2013.01)] | 32 Claims |

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1. A computer system, comprising:
a processor; and
memory coupled to the processor and comprising instructions that, when executed, cause the processor to perform a method used for planning radiation treatment of a target volume in a patient, the method comprising:
accessing, from the memory, a first candidate radiation treatment plan comprising information describing a spatial distribution of radiation beams;
determining a distribution of dose in a volume of tissue that is outside of the target volume and intersected by the radiation beams;
determining a value of a metric that is a function of the distribution of the dose in the volume of the tissue; and
evaluating the first candidate radiation treatment plan using the value of the metric.
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