US 12,403,316 B2
Neural interface device for stimulation of a nerve and measuring impedance
Refet Firat Yazicioglu, Brentford (GB); Rizwan Bashirullah, Brentford (GB); and Gerald Edwin Hunsberger, Jr., Brentford (GB)
Assigned to GALVANI BIOELECTRONICS LIMITED, Stevenage (GB)
Appl. No. 16/619,392
Filed by Galvani Bioelectronics Limited, Brentford (GB)
PCT Filed Dec. 20, 2018, PCT No. PCT/GB2018/053728
§ 371(c)(1), (2) Date Dec. 4, 2019,
PCT Pub. No. WO2019/122905, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/608,438, filed on Dec. 20, 2017.
Prior Publication US 2020/0306534 A1, Oct. 1, 2020
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/3614 (2017.08) [A61N 1/0556 (2013.01); A61N 1/36175 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A system for stimulation of a nerve and measuring impedance, the system comprising:
a plurality of electrodes;
a voltage or current source operatively connected to at least a subset of the plurality of electrodes, wherein the voltage or current source is configured to generate an electrical signal to be applied to said subset of the plurality of electrodes;
an impedance measurement module operatively connected to at least the subset of the plurality of electrodes, wherein the impedance measurement module is configured to measure the impedance between said subset of the plurality of electrodes,
wherein the impedance measurement module is further configured to measure a relative change in impedance between a baseline impedance measured before an application of the electrical signal and an impedance measured after the application of the electrical signal comprising a sequence of stimulation pulses, across the plurality of electrodes; and
a controller arranged to determine a dose response induced by the electrical signal,
wherein the dose response is determined using relationship definitions based upon correlation data between impedance change and the dose response,
wherein the dose response is an indication of a downstream effect, and
wherein the controller is arranged to adjust the electrical signal in order to induce a target dose response.